The OptiScanner® Glucose Monitoring System has been the subject of multiple clinical studies in critically ill patients.

Clinically studied in 11 human trials including 667 patients and 10,419 paired data points.1

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In healthy diabetics, 99% of patients in Clarke Error Grid zone A2

In critically ill patients, 99.9% of patients in Clarke Error Grid zone A and B3,4

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In a septic patients study, glucose maintained at target 93% of the time5

1. Summary data on file. OptiScan Biomedical.    2. Jax, et al. J Diabetes Sci Technical 2011,5(2):345-352    3. Van Hooijdonk, et al. Annals of Intensive Care 2014, 4:8 4. Righy Shinotsuka, et al. Crit Care. 2016 Nov 25;20(1):380 5. Umbrello, et al. Clinical Nutrition 2013.

OptiScanner Peer-Reviewed Clinical Studies

Righy Shinotsuka C, Brasseur A, Fagnoul D, So T, Vincent JL, Preiser JC. Manual versus Automated moNitoring Accuracy of GlucosE II (MANAGE II). Crit Care. 2016 Nov 25;20(1):380  Abstract

Nohra E, Buckman S, Bochicchio K, Chamieh J, Reese S, Merrill C, Schuerer D, Bochicchio GV. Results of a near continuous glucose monitoring technology in surgical intensive care and trauma. Contemp Clin Trials Sep 2016;50:1-4  Abstract

Barassi A, Umbrello M, Ghilardi F, Damele CA, Massaccesi L, Iapichino G, Melzi d’Eril GV. Evaluation of the performance of a new OptiScanner™ 5000 system for an intermittent glucose monitoring. Clin Chim Acta 2015 Jan 1;438  Abstract

Van Hooijdonk R, Winters T, Fischer JC, van Dongen-Lases EC, Krinsley J, Preiser JC, Schultz M.  Accuracy and limitations of continuous glucose monitoring using spectroscopy in critically ill patients. Annals of Intensive Care 2014, 4:8  Paper

Umbrello M, Salice V, Spanu P, Formenti P, Barassi A, Melzi d’Eril GV, Iapichino G.  Performance assessment of a glucose control protocol in septic patients with an automated intermittent plasma glucose monitoring device.  Clin Nutr 2013  Abstract

Krinsley J, Bochicchio K, Calentine C, Bochicchio G.  Glucose measurements of intensive care unit patient plasma samples using a fixed-wavelength mid-infrared spectroscopy system.   J Diabetes Sci Technol 2012;6920;294-301  Paper

Jax T, Jeise T, Nosek L, Gable J, Lim G, Calentine, C.  Automated near-continuous glucose monitoring measured in plasma using mid-infrared spectroscopy.  J Diabetes Sci Technol 2011;5(2):345-352  Paper

Magarian P, Bernhard S.  Plasma-generating glucose monitor accuracy demonstrated in an animal model.  J Diabetes Sci Technol 2009;3(6):1411-1418  Paper

 

Related Clinical Studies and Articles – Glycemic Control in the ICU

Krinsley, J. Glycaemic Control in the Critically Ill: What Have We Learned Since NICE-SUGAR? ICU 2014, 14:1  Article

Lanspa MJ, Dickerson J, Morris AH, Orme JF, Holmen J, Hirshberg EL. Coefficient of glucose variation is independently associated with mortality in critically ill patients receiving intravenous insulin. Critical Care 2014, 18:R86 Paper

Finfer S, Wernerman J, Preiser JC, et al. Clinical review: Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults. Critical Care 2013;17:229  Paper

Inoue S, Egi M, Kotani J, Morita, K. Accuracy of blood-glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review. Critical Care 2013; 17:R48  Paper

Krinsley JS, Schultz MJ, Spronk PE, Harmsen RE, van Braam Houckgeest F, van der Sluijs JP, Mélot C, Preiser JC. Mild hypoglycemia is independently associated with increased mortality in the critically ill. Crit Care. 2011, 15:R173 Paper

Krinsley J et al. Mild hypoglycemia is strongly associated with increased intensive care unit length of stay. Annals of Intensive Care 2011, 1:49  Paper

Egi M, Bellomo R, Stachowski E, French CJ, Hart GK, Taori G, Hegarty C, Bailey M. Hypoglycemia and Outcome in Critically Ill Patients. Mayo Clin Proc. 2010 March; 85:3:217-24 Paper

Falciglia M, Freyberg R, Almenoff P, D’Alessio D, Render M. Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. Crit Care Med 2009;37(12):3001-3009  Paper

Dungan K, et al.  Glucose measurement: confounding issues in setting targets for inpatient management.  Diabetes Care 2007;30:403-409  Paper

Krinsley, J and Jones R. Cost Analysis of Intensive Glycemic Control in Critically Ill Adult Patients. Chest 2006;129: 644-650  Paper

Krinsley JS. Association Between Hyperglycemia and Increased Hospital Mortality in a Heterogeneous Population of Critically Ill Patients. Mayo Clin Proc. 2003 Dec; 78:12:1471-8 Paper

 

Related Clinical Studies and Articles – Glucose Monitoring in Clinical Practice

Jeschke, MG. Clinical review: Glucose control in severely burned patients – current best practice. Critical Care 2013, 17:232  Paper

Martin GS. Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther. Jun 2012; 10(6): 701-706. DOI: 10.1586/eri.12.50  Paper

Lazar, et al.  The Society of Thoracic Surgeons Practice Guidelines Series:  Blood Glucose Management During Adult Cardiac Surgery.  Ann Thorac Surg 2009;87:663-9  Paper

Leonido L, Michalaki M, Leonardoi A, et al. Stress-Induced Hyperglycemia in Patients with Severe Sepsis: A Compromising Factor for Survival. Am J Med Sci 2008: 336(6):467-471  Abstract

Furnary, Anthony P. Rationale for Glycemic Control in Cardiac Surgical Patients: The Portland Diabetic Project. Insulin 2006;1: S24–S29  Abstract

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CAUTION: In the U.S., the OptiScanner system is an investigational device limited by Federal (U.S.) law to investigational use. This investigational product has not been cleared or approved by the U.S. Food and Drug Administration for marketing in the United States.
OptiScan Biomedical has received CE Mark certification for the OptiScanner 5000 system.